Researches

Epigenetic histone modification research

Histone proteins and the nucleosomes are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications (PTMs) of histones has been well documented, such as acetylation, methylation, phosphorylation and ubiquitination, etc.

Epigenetic non-histone modifications

Modification of non-histone proteins is involved in various cellular pathways including in the development and progression of various diseases including cancers. An increasing number of non-histone protein substrates are being modified by various histone modifiers.

Epigenetic regulation of leukemogenesis and leukemia cell differentiation

We tried to identify mechanisms of leukemia cell differentiation using ChIP-seq, microarray, and global histone medication changes for combinational effects of leukemia cell differentiation.

Recent Publications

2023

  • Park, J., Luo, Y., Park, J.W., Kim, S.H., Hong, Y.J., Lim, Y., Seo, Y.J., Bae, J.  and Seo, S.B.* (2023). Downregulation of DNA methylation enhances differentiation of THP‑1 cells and induces M1 polarization of differentiated macrophages. Sci Rep. 13(1):13132. [PubMed] (*Corresponding author)
  • Park, J.†, Kim, J.Y.†, Park, J.W., Kang, J.Y., Oh, H., Hahm, J.Y., Chae, Y.C., Chakravarti, D.  and Seo, S.B.* (2023). INHAT subunit  SET/TAF-Iβ regulates PRC1 independent H2AK119 mono-ubiquitination via E3 ligase MIB1 in colon cancer. NAR Cancer. 5(3). [PubMed] (†Co-first authors, *Corresponding author)

2022

  • Hong, Y.J., Park, J., Hahm, J.Y., Kim, S.H., Lee, D.H., Park, K.S. and Seo, S.B.* (2022). Regulation of UHRF1 acetylation by TIP60 is important for colon cancer cell proliferationDM2B and SET7 in the regulation of skeletal muscle differentiation. Genes Genomics. 44(11):1353-1361. [PubMed] (*Corresponding author)
  • Kim, S.H., Park, J., Park, J.W., Hahm, J.Y., Yoon, S., Hwang, I.J., Kim, K.P. and Seo, S.B.* (2022). SET7-mediated TIP60 methylation is essential for DNA double-strand break repair. BMB Rep. 55(11):541-546. [PubMed] (*Corresponding author)
  • Hwang, I.J.†, Park, J.† and Seo, S.B.* (2022). Non-canonical transcriptional regulation of INHAT subunit SET/TAF-Iβ by EZH2 . Biochem Biophys Res Commun. 635:136-143. [PubMed] (†Co-first authors, *Corresponding author)

2021

  • Kwon, D.H.†, Kang, J.Y.†, Joung, H.†, Kim, J.Y., Jeong, A., Min, H.K., Shin, S., Lee, Y.G., Kim, Y.K., Seo, S.B.* and Kook, H.* (2021). SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation. Exp Mol Med. 53(2):250-263. [PubMed] (†Co-first authors, *Corresponding authors)
  • Kim, H.J., Park, J.W., Kang, J.Y. and Seo, S.B.* (2021). Negative regulation of erythroid differentiation via the CBX8-TRIM28 axis. Mol Cells. 44(7):444-457. [PubMed] (*Corresponding author)
  • Kang, J.Y.†, Park, J.W.†, Hwang, Y.†, Hahm, J.Y., Park, J., Park, K.S. and Seo, S.B.* (2021). The H3K4 methyltransferase SETD1A is required for proliferation of non-small lung cancer cells by promoting S-phase progression. Biochem Biophys Res Commun. 561:120-127. [PubMed] (†Co-first authors, *Corresponding author)

2020

  • Hahm, J.Y.†, Kang, J.Y.†, Park, J.W., Jung, H. and Seo, S.B.* (2020). Methylated-UHRF1 and PARP1 interaction is critical for homologous recombination. BMB Rep. 53(2), 112-117. [PubMed] (†Co-first authors, *Corresponding author)
  • Jung, H. and Seo, S.B.* (2020). Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes. PLoS One. 15(7), e0236403. [PubMed] (*Corresponding author)
  • Hahm, J.Y., Park, J.W., Kang, J.Y., Park, J., Kim, C.H., Kim, J.Y., Ha, N.C., Kim, J.W. and Seo, S.B.* (2020). Acetylation of UHRF1 Regulates Hemi-methylated DNA Binding and Maintenance of Genome-wide DNA Methylation. Cell Rep. 32(4), 107958. [PubMed] (*Corresponding author)
  • Park, J.W., Kang, J.Y., Hahm, J.Y., Kim, H.J. and Seo, S.B.* (2020). Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation. Commun Biol. 3(1), 462. [PubMed] (*Corresponding author)
  • Kang, J.Y., Park, J.W., Hahm, J.Y., Jung, H. and Seo, S.B.* (2020). Histone H3K79 demethylation by KDM2B facilitates proper DNA replication through PCNA dissociation from chromatin. Cell Prolif. e12920. [PubMed] (*Corresponding author)

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